Quantitative assessment of macrophage functions in repair and fibrosis.

@article{Wynn2011QuantitativeAO,
  title={Quantitative assessment of macrophage functions in repair and fibrosis.},
  author={Thomas A. Wynn and Luke Barron and Robert W Thompson and Satish K. Madala and Mark S Wilson and Allen W. Cheever and Thirumalai R. Ramalingam},
  journal={Current protocols in immunology},
  year={2011},
  volume={Chapter 14},
  pages={Unit14.22}
}
Macrophages play key roles in wound repair and fibrosis by regulating extracellular matrix turnover. Macrophages can process matrix components themselves, but also recruit and alter the functions of other cell types that directly build or degrade extracellular matrix. Classically activated macrophages (CAM, also called M1) tend to promote tissue injury while alternatively activated macrophages (AAM, also called M2) are often linked with the mechanisms of wound repair and fibrosis. However… CONTINUE READING

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