Quantitative assessment of intervertebral disc glycosaminoglycan distribution by gadolinium-enhanced MRI in orthopedic patients.

@article{Vaga2008QuantitativeAO,
  title={Quantitative assessment of intervertebral disc glycosaminoglycan distribution by gadolinium-enhanced MRI in orthopedic patients.},
  author={Stefania Vaga and Manuela Teresa Raimondi and Enrico G. Caiani and Francesco Vittorio Costa and Carmen Giordano and Franco Perona and Alberto Zerbi and M. Fornari},
  journal={Magnetic resonance in medicine},
  year={2008},
  volume={59 1},
  pages={85-95}
}
Our hypothesis was that the enhanced MRI of cartilage (dGEMRIC) imaging protocol could be used in patients to quantify the sulfated glycosaminoglycan (sGAG) in intervertebral discs (IVD). To test this hypothesis, 23 patients with degenerative disc pathology scheduled for surgery were studied by a specific dGEMRIC protocol: each patient underwent two MRI scans, before and 3.5 hr after Gd(DTPA)2-injection of a nonconventional dose of 40 mL. Then, T(1PRE-ENH) and T(1POST-ENH) parametric images of… CONTINUE READING

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