Quantitative assessment of in vitro interactions implicates TATA-binding protein as a target of the VP16C transcriptional activation region.

@article{Nedialkov2004QuantitativeAO,
  title={Quantitative assessment of in vitro interactions implicates TATA-binding protein as a target of the VP16C transcriptional activation region.},
  author={Yuri A. Nedialkov and Steven J. Triezenberg},
  journal={Archives of biochemistry and biophysics},
  year={2004},
  volume={425 1},
  pages={
          77-86
        }
}
Models of mechanisms of transcriptional activation in eukaryotes frequently invoke direct interactions of transcriptional activation domains with target proteins including general transcription factors or coactivators such as chromatin modifying complexes. The potent transcriptional activation domain (AD) of the VP16 protein of herpes simplex virus has previously been shown to interact with several general transcription factors including the TATA-binding protein (TBP), TBP-associated factor 9… CONTINUE READING

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