Quantitative assessment of hypoxia kinetic models by a cross-study of dynamic 18F-FAZA and 15O-H2O in patients with head and neck tumors.

@article{Shi2010QuantitativeAO,
  title={Quantitative assessment of hypoxia kinetic models by a cross-study of dynamic 18F-FAZA and 15O-H2O in patients with head and neck tumors.},
  author={Kuangyu Shi and Michael Souvatzoglou and Sabrina T. Astner and Peter Vaupel and Fridtjof N{\"u}sslin and Jan J. Wilkens and Sibylle Ilse Ziegler},
  journal={Journal of nuclear medicine : official publication, Society of Nuclear Medicine},
  year={2010},
  volume={51 9},
  pages={1386-94}
}
UNLABELLED Several kinetic models have been proposed to assess the underlying oxygenation status behind hypoxia tracer uptake and have shown advantages, compared with static analysis, in discriminating hypoxic regions. However, the quantitative assessment of mathematic models that take into consideration clinical applications and their biologic nature is still challenging. We performed a feasibility study to assess hypoxia kinetic models using voxelwise cross-analysis between the uptake of the… CONTINUE READING
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