Quantitative assessment of anaplerosis from propionate in pig heart in vivo.

@article{Martini2003QuantitativeAO,
  title={Quantitative assessment of anaplerosis from propionate in pig heart in vivo.},
  author={Wenjun Z. Martini and William Chad Stanley and Hazel H. Huang and Christine Des Rosiers and Charles L. Hoppel and Henri Brunengraber},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2003},
  volume={284 2},
  pages={
          E351-6
        }
}
Normal cardiac metabolism requires continuous replenishment (anaplerosis) of catalytic intermediates of the citric acid cycle. Little is known about the quantitative aspects of propionate as a substrate of in vivo anaplerosis; therefore, we measured the rate of propionate entry into the citric acid cycle in hearts of anesthetized pigs. [U-(13)C(3)]propionate (0.25 mM) was infused in a coronary artery branch for 1 h via an extracorporeal perfusion circuit, and cardiac biopsies were analyzed for… CONTINUE READING

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 15 CITATIONS

Regulation of ketone body and coenzyme A metabolism in liver

VIEW 3 EXCERPTS
CITES METHODS
HIGHLY INFLUENCED

Propionate stimulates pyruvate oxidation in the presence of acetate.

  • American journal of physiology. Heart and circulatory physiology
  • 2014
VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 29 REFERENCES

Partitioning of pyruvate between oxidation and anaplerosis in swine hearts.

  • American journal of physiology. Heart and circulatory physiology
  • 2000
VIEW 6 EXCERPTS

Acute hibernation decreases myocardial pyruvate carboxylation and citrate release.

  • American journal of physiology. Heart and circulatory physiology
  • 2001
VIEW 3 EXCERPTS

Mitochondrial fatty acid oxidation disorders. In: The Metabolic and Molecular Bases of Inherited Diseases, edited by Scriver CR

CR Roe, JH Ding
  • Beaudet AL, Sly WS, and Valle D. New York: McGraw-Hill,
  • 2001
VIEW 1 EXCERPT

Intravenous pyruvate prolongs survival during hemorrhagic shock in swine.

  • American journal of physiology. Heart and circulatory physiology
  • 1999
VIEW 2 EXCERPTS