Quantitative assessment of Wilms tumor 1 (WT1) gene transcripts in Egyptian acute lymphoblastic leukemia patients.

@article{Sadek2011QuantitativeAO,
  title={Quantitative assessment of Wilms tumor 1 (WT1) gene transcripts in Egyptian acute lymphoblastic leukemia patients.},
  author={Hoda Ali Sadek and Wafaa Hassan El-Metnawey and Iman Abdel-Mohsen Shaheen and Mervat Mamdouh Korshied and Azza Sobieh Mohamed},
  journal={Journal of investigative medicine : the official publication of the American Federation for Clinical Research},
  year={2011},
  volume={59 8},
  pages={1258-62}
}
BACKGROUND Accurate assessment of minimal residual disease (MRD) in acute lymphoblastic leukemia (ALL) patients after initial chemotherapy is essential to evaluate the efficacy of therapeutic regimens. Wilms tumor 1 (WT1) is a pan-leukemic marker used for identification of the leukemic clone rather than the use of individual specific molecular aberration of ALL. METHODS Using a real-time quantitative polymerase chain reaction, bone marrow samples from 41 newly diagnosed Egyptian ALL patients… CONTINUE READING
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