Quantitative assessment concerning the contribution of IL-2Rbeta for superantigen-mediated T cell responses in vivo.

@article{Jin2006QuantitativeAC,
  title={Quantitative assessment concerning the contribution of IL-2Rbeta for superantigen-mediated T cell responses in vivo.},
  author={Haoli Jin and Dapeng Gong and Dennis Adeegbe and Allison L Bayer and Cleo E. Rolle and Aixin Yu and Thomas R Malek},
  journal={International immunology},
  year={2006},
  volume={18 4},
  pages={565-72}
}
IL-2- and IL-2R-deficient mice readily develop T cell-dependent immune responses in vivo, but the relevance of this finding is complicated by severe concurrent autoimmunity. Furthermore, the detection of such responses does not address whether under normal circumstances IL-2 dominates T cell immunity. In the present report, we investigated the extent IL-2-independent T cell growth is mediated by other cytokines in the IL-2 family and compared such responses to those generated by IL-2/IL-2R… CONTINUE READING