Quantitative assays for anti-aquaporin-4 antibody with subclass analysis in neuromyelitis optica.

@article{Isobe2012QuantitativeAF,
  title={Quantitative assays for anti-aquaporin-4 antibody with subclass analysis in neuromyelitis optica.},
  author={Noriko Isobe and Tomomi Yonekawa and Takuya Matsushita and Yuji Kawano and Katsuhisa Masaki and Satoshi Yoshimura and Jakub Fichna and Shu Shin Chen and Jadwiga Furmaniak and Bernard Rees Smith and Jun-ichi Kira},
  journal={Multiple sclerosis},
  year={2012},
  volume={18 11},
  pages={1541-51}
}
BACKGROUND To clarify the clinical relevance of anti-aquaporin-4 (anti-AQP4) antibody titers and immunoglobulin (IgG) subclass. METHODS Using a bridging enzyme-linked immunosorbent assay (ELISA), a flow cytometric assay (FCMA) and an immunofluorescence assay (IFA) for anti-AQP4 antibodies, sera from 142 patients with multiple sclerosis (MS) as defined by the McDonald criteria (2005), 29 with neuromyelitis optica (NMO) who fulfilled the 1999 criteria, 19 with recurrent and/or longitudinally… CONTINUE READING