Quantitative and ultrastructural changes of peritoneal macrophages in immunized rats after intraperitoneal injection of Novikoff hepatoma.


The response of peritoneal cells to transplantable Novikoff hepatoma was studied in immunized and nonimmunized inbred male SD rats to elucidate the role of macrophages in syngeneic tumor rejection. Specific immunization was induced by double sc challenge with viable tumor cells. Peritoneal cells were harvested by lavage at intervals of 6 hours and 1, 2, 3… (More)


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