Quantitative and transformation product analysis of major active physalins from Physalis alkekengi var. franchetii (Chinese lantern) using ultraperformance liquid chromatography with electrospray ionisation tandem mass spectrometry and time-of-flight mass spectrometry.

@article{Zheng2012QuantitativeAT,
  title={Quantitative and transformation product analysis of major active physalins from Physalis alkekengi var. franchetii (Chinese lantern) using ultraperformance liquid chromatography with electrospray ionisation tandem mass spectrometry and time-of-flight mass spectrometry.},
  author={Yunliang Zheng and Yong Chen and Yiping Ren and L. Luan and Yongjiang Wu},
  journal={Phytochemical analysis : PCA},
  year={2012},
  volume={23 4},
  pages={
          337-44
        }
}
INTRODUCTION Chinese lantern is the calyx or calyx-with-fruit of the plant Physalis alkekengi .var. franchetii (Solanaceae), and is potential material for the food and pharmaceutical industries. Physalins are the most active and representative secondary metabolites of Chinese lantern. A separation and quantification method based on UPLC-ESI-MS/MS was developed for the quantitative analysis of five active physalins. The transformation products were also detected and identified for the first time… Expand
Characterization of physalins and fingerprint analysis for the quality evaluation of Physalis alkekengi L. var. franchetii by ultra-performance liquid chromatography combined with diode array detection and electrospray ionization tandem mass spectrometry.
TLDR
The proposed method provides a scientific and technical platform to the herbal industry for quality control and safety assurance of herbal preparations that contain this class of physalins. Expand
High performance thin-layer chromatography-mass spectrometry enables reliable analysis of physalins in different plant parts of Physalis alkekengi L.
We developed first HPTLC and HPTLC-MS/MS methods which enable characterization of structurally similar and complex biologically active compounds - physalins - from crude extracts of Chinese lanternExpand
LC-MS/MS method for simultaneous determination of flavonoids and physalins in rat plasma: Application to pharmacokinetic study after oral administration of Physalis alkekengi var. franchetii (Chinese lantern) extract.
TLDR
A rapid and sensitive liquid chromatography with tandem mass spectrometry (LC-MS/MS) method was developed and validated and successfully applied for the first time to the pharmacokinetic study of five ingredients after oral administration of 70% ethanol extract of Chinese lantern in rats. Expand
Identification of absorbed constituents and in vivo metabolites in rats after oral administration of Physalis alkekengi var. franchetii by ultra-high-pressure liquid chromatography quadrupole time-of-flight mass spectrometry.
TLDR
This is the first systematic study on the absorbed constituents and metabolic profiling of JDL and will provide a useful template for screening and characterizing the ingredients and metabolites of traditional Chinese medicine. Expand
Development and Validation of RP-HPLC Method for the Simultaneous Quantification of Seven Flavonoids in Pericarpium Citri reticulatae
In this study, a reversed phase high performance liquid chromatography (RP-HPLC) method was developed and validated for simultaneous quantification of seven flavonoids including nobiletin,Expand
Identification and quantitative analysis of physalin D and its metabolites in rat urine and feces by liquid chromatography with triple quadrupole time-of-flight mass spectrometry.
TLDR
The results indicate that the extensive and rapid metabolism may be the main factors leading to the short half-life of physalin D. Expand
Improved stability of salvianolic acid B from Radix Salviae miltiorrhizae in deep eutectic solvents
Deep eutectic solvents (DESs) have numerous chemical applications as environmentally green solvents due to their unique physicochemical properties. In this study, the stability of salvianolic acid BExpand
A Simple Validated HPTLC Method for Simultaneous Analysis of Colchicine and Gallic Acid in Polyherbal Formulation: Habb-E-Irqun-Nisha
A simple and affordable high-performance thin-layer chromatographic (HPTLC) method has been established for simultaneous analysis of colchicine (CL) and gallic acid (GA), which are present togetherExpand
In vivo pharmacokinetics of and tissue distribution study of physalin B after intravenous administration in rats by liquid chromatography with tandem mass spectrometry.
TLDR
A pharmacokinetic study showed that physalin B has a long dwell time with a half-life of 321.2 ± 29.5 min and clearance of 175.7 mL/min/kg after intravenous administration and a wide tissue distribution with a special higher penetration in lung. Expand
Physalis alkekengi var. franchetii Extracts Exert Antitumor Effects on Non-Small Cell Lung Cancer and Multiple Myeloma by Inhibiting STAT3 Signaling
Background Physalis alkekengi var. franchetii is an herb that possesses various ethnopharmacological applications. Herein, our current study focuses on the antitumor effect of a combination ofExpand
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A pair of 3-epimeric physalins from Physalis alkekengi L. var. franchetii
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Physalin and neophysalins from Physalis alkekengi var. francheti and their differentiation inducing activity
A methanol extract of Physalis alkekengi var. francheti showed a potent cell differentiation inducing activity toward mouse myeloid leukemia cell line (M1 cells). From the extract, a new physalin andExpand
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