Quantitative and stoichiometric analysis of the microRNA content of exosomes.

@article{Chevillet2014QuantitativeAS,
  title={Quantitative and stoichiometric analysis of the microRNA content of exosomes.},
  author={John R Chevillet and Qing Kang and Ingrid K. Ruf and Hilary A Briggs and Lucia Vojtech and Sean M Hughes and Heather H Cheng and Jason D. Arroyo and Emily K Meredith and Emily N. Gallichotte and Era L. Pogosova-Agadjanyan and Colm M Morrissey and Derek L. Stirewalt and Florian Hladik and Evan Y Yu and Celestia S. Higano and Muneesh Tewari},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 41},
  pages={14888-93}
}
Exosomes have been proposed as vehicles for microRNA (miRNA) -based intercellular communication and a source of miRNA biomarkers in bodily fluids. Although exosome preparations contain miRNAs, a quantitative analysis of their abundance and stoichiometry is lacking. In the course of studying cancer-associated extracellular miRNAs in patient blood samples, we found that exosome fractions contained a small minority of the miRNA content of plasma. This low yield prompted us to perform a more… CONTINUE READING
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via TLR 7 and TRPA 1

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