Quantitative and stoichiometric analysis of the microRNA content of exosomes.

  title={Quantitative and stoichiometric analysis of the microRNA content of exosomes.},
  author={John R Chevillet and Qing Kang and Ingrid K. Ruf and Hilary A Briggs and Lucia Vojtech and Sean M Hughes and Heather H Cheng and Jason D. Arroyo and Emily K Meredith and Emily N. Gallichotte and Era L. Pogosova-Agadjanyan and Colm M Morrissey and Derek L. Stirewalt and Florian Hladik and Evan Y Yu and Celestia S. Higano and Muneesh Tewari},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={111 41},
Exosomes have been proposed as vehicles for microRNA (miRNA) -based intercellular communication and a source of miRNA biomarkers in bodily fluids. Although exosome preparations contain miRNAs, a quantitative analysis of their abundance and stoichiometry is lacking. In the course of studying cancer-associated extracellular miRNAs in patient blood samples, we found that exosome fractions contained a small minority of the miRNA content of plasma. This low yield prompted us to perform a more… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 34 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 174 extracted citations


Publications referenced by this paper.
Showing 1-10 of 54 references

via TLR 7 and TRPA 1

  • KT Gagnon, L Li, Y Chu, BA Janowski, DR Corey
  • Neuron
  • 2014

Similar Papers

Loading similar papers…