Quantitative and qualitative studies of antibody-induced mesangial cell damage in the rat.

@article{Yamamoto1987QuantitativeAQ,
  title={Quantitative and qualitative studies of antibody-induced mesangial cell damage in the rat.},
  author={Takahiko Yamamoto and Christopher B Wilson},
  journal={Kidney international},
  year={1987},
  volume={32 4},
  pages={
          514-25
        }
}
Intravenous administration of heterologous anti-rat thymocyte serum (ATS), which reacts with a Thy-1-like antigen present on rat glomerular mesangial cells, caused lytic (1 hr to 2 days), hypercellular (4 to 14 days), and sclerotic (2 to 3 months) mesangial lesions in Lewis rats. The normal control of 48.6 +/- 7.9 (mean +/- SD) glomerular nuclei on histologic section decreased significantly (P less than 0.001) to 39.8 +/- 6.1, 37.4 +/- 6.0, and 38.9 +/- 6.8 at one hour, four hours and two days… CONTINUE READING

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