Quantitative and morphometric evaluation of the angiogenic effects of leptin.

  title={Quantitative and morphometric evaluation of the angiogenic effects of leptin.},
  author={Dodanim Talavera-Adame and Yizhi Xiong and Tong Zhao and Ana Arias and M. Rocio Sierra-Honigmann and Daniel L. Farkas},
  journal={Journal of biomedical optics},
  volume={13 6},
Angiogenesis is a dynamic process that requires an interaction of pro-and antiangiogenic factors. It is known that the cytokine leptin stimulates endothelial cell growth and angiogenesis, but further quantitative analysis is necessary to understand leptin angiogenic effects. The quail chorioallantoic membrane (CAM) assay has been used to study angiogenesis in vivo by focusing on morphometric parameters that quantify vascular complexity and density. We quantify the angiogenic activity of leptin… CONTINUE READING


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