Quantitative and integrated proteome and microRNA analysis of endothelial replicative senescence.


Age-related changes in vascular functioning are a harbinger of cardiovascular disease but the biological mechanisms during the progression of endothelial senescence have not been studied. We investigated alterations in the proteome and miRNA profiles in the course of replicative senescence using primary human umbilical vein endothelial cells as an in vitro… (More)
DOI: 10.1016/j.jprot.2015.05.023

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