Quantitative and functional evaluation of innate immune responses in patients with common variable immunodeficiency.

Abstract

OBJECTIVES We evaluate the frequency and functional response of innate immune cells in peripheral blood (PB) from patients with common variable immunodeficiency (CVID) and healthy controls upon activation with agonists of the Toll-like receptors (TLR) TLR2, TLR4, and TLR9. In addition, several nonsynonymous single nucleotide polymorphisms (SNPs) within… (More)

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