Quantitative and functional characteristics of intestinal-homing memory T cells: analysis of Crohn's disease patients and healthy controls.

@article{Hart2004QuantitativeAF,
  title={Quantitative and functional characteristics of intestinal-homing memory T cells: analysis of Crohn's disease patients and healthy controls.},
  author={Ailsa L. Hart and M. Kamm and Stella C. Knight and Andrew J. Stagg},
  journal={Clinical and experimental immunology},
  year={2004},
  volume={135 1},
  pages={137-45}
}
Circulating memory T cells can be subdivided on the basis of beta7 integrin expression. The beta7+ population contains cells primed in the intestine capable of homing back to the gut. We hypothesized that cytokine production by beta7+ memory T cells reflects the specialized mucosal compartment in which they were primed. Flow cytometry of whole blood was used to assess numbers of beta7+ (beta7hi and beta7int) and beta7- memory T cells and their production of Th1 and regulatory cytokines in… CONTINUE READING

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