Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis.

@article{Kita2002QuantitativeAF,
  title={Quantitative and functional analysis of PDC-E2-specific autoreactive cytotoxic T lymphocytes in primary biliary cirrhosis.},
  author={Hiroto Kita and Shuji Matsumura and X He and Aftab A Ansari and Zhe-xiong Lian and Judy Van de Water and Ross L Coppel and Marshall M. Kaplan and M Eric Gershwin},
  journal={The Journal of clinical investigation},
  year={2002},
  volume={109 9},
  pages={1231-40}
}
While the pathologic mechanisms responsible for organ-specific tissue damage in primary biliary cirrhosis (PBC) remain an enigma, it has been suggested that the pathology is mediated by autoreactive T cells infiltrating the intrahepatic bile ducts. Previously, we have documented that there is 100-fold enrichment in the frequency of CD4(+) autoreactive T cells in the liver that are specific for peptides encoded by the E2 components of the pyruvate dehydrogenase complexes (PDC-E2). We have also… CONTINUE READING

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