Quantitative and Systems Pharmacology 3. Network-Based Identification of New Targets for Natural Products Enables Potential Uses in Aging-Associated Disorders
@article{Fang2017QuantitativeAS, title={Quantitative and Systems Pharmacology 3. Network-Based Identification of New Targets for Natural Products Enables Potential Uses in Aging-Associated Disorders}, author={Jiansong Fang and Li Gao and Huili Ma and Qihui Wu and Tian Wu and Jun Wu and Qi Wang and Feixiong Cheng}, journal={Frontiers in Pharmacology}, year={2017}, volume={8} }
Aging that refers the accumulation of genetic and physiology changes in cells and tissues over a lifetime has been shown a high risk of developing various complex diseases, such as neurodegenerative disease, cardiovascular disease and cancer. Over the past several decades, natural products have been demonstrated as anti-aging interveners via extending lifespan and preventing aging-associated disorders. In this study, we developed an integrated systems pharmacology infrastructure to uncover new…
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References
SHOWING 1-10 OF 83 REFERENCES
Current Perspective in the Discovery of Anti-aging Agents from Natural Products
- BiologyNatural Products and Bioprospecting
- 2017
These compounds or extracts and their mechanisms in increasing longevity of Caenorhabditis elegans or other species, and the prospect in developing anti-aging medicine from natural products are summarized.
Quantitative and Systems Pharmacology. 1. In Silico Prediction of Drug-Target Interactions of Natural Products Enables New Targeted Cancer Therapy.
- BiologyJournal of chemical information and modeling
- 2017
This study reconstructed a global drug-target network with 7,314 interactions connecting 751 targets and 2,388 natural products and built predictive network models via a balanced substructure-drug- target network-based inference approach and showed that the significantly predicted anticancer indications of multiple natural products with new mechanism-of-action were validated.
Molecular mechanisms for anti-aging by natural dietary compounds.
- MedicineMolecular nutrition & food research
- 2012
This review summarizes the current understanding on signaling pathways of aging and knowledge and underlying mechanism of natural dietary compounds that provide potential application on anti-aging and improve heath in human.
Computational prediction of microRNA networks incorporating environmental toxicity and disease etiology
- BiologyScientific reports
- 2014
A computational systems toxicology framework to predict new associations among EFs, miRNAs and diseases by integrating EF structure similarity and disease phenotypic similarity is developed and successfully inferred novel EF-miRNAs networks in two case studies for breast cancer and cigarette smoke.
In silico polypharmacology of natural products
- BiologyBriefings Bioinform.
- 2018
The promise of cancer immunotherapies and combination therapies that target tumor ecosystems (e.g. clones or 'selfish' sub-clones) via exploiting the immunological and inflammatory 'side' effects of natural products in the cancer post-genomics era is highlighted.
In search for geroprotectors: in silico screening and in vitro validation of signalome-level mimetics of young healthy state
- BiologyAging
- 2016
PD-98059, a highly selective MEK1 inhibitor, showed both life-prolonging and rejuvenating effects and natural compounds like N-acetyl-L-cysteine, Myricetin and Epigallocatechin gallate improved several senescence-associated properties and were further investigated with pathway analysis.
Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer’s Therapy?
- BiologyFront. Aging Neurosci.
- 2017
Examination of recent evidence suggests that inhibition of protein tyrosine phosphatase 1B (PTP1B) may represent a promising strategy to combat a variety of AD-related detrimental processes.
Systems Pharmacology‐Based Discovery of Natural Products for Precision Oncology Through Targeting Cancer Mutated Genes
- BiologyCPT: pharmacometrics & systems pharmacology
- 2017
An integrated systems pharmacology framework was developed that facilitated identifying potential natural products that target mutated genes across 15 cancer types or subtypes in the realm of precision medicine and provides a powerful tool for the development of molecularly targeted cancer therapies.
Aging and drug discovery
- Medicine, BiologyAging
- 2018
A consensus is emerging both in industry and academia, that molecules able to intervene in the aging process may contain the potential to transform both societies and healthcare.