Quantitative and Dynamic Assessment of the Contribution of the ER to Phagosome Formation

@article{Touret2005QuantitativeAD,
  title={Quantitative and Dynamic Assessment of the Contribution of the ER to Phagosome Formation},
  author={Nicolas Touret and Paul Paroutis and Mauricio R Terebiznik and Rene E. Harrison and Sergio E Trombetta and Marc Pypaert and Amy Chow and Aimin Jiang and James Shaw and Christopher M Yip and H Moore and Nicole N. van der Wel and Diane Houben and Peter J Peters and Chantal de Chastellier and Ira Mellman and Sergio Grinstein},
  journal={Cell},
  year={2005},
  volume={123},
  pages={157-170}
}
Phagosomes were traditionally thought to originate from an invagination and scission of the plasma membrane to form a distinct intracellular vacuole. An alternative model implicating the endoplasmic reticulum (ER) as a major component of nascent and maturing phagosomes was recently proposed (Gagnon et al., 2002). To reconcile these seemingly disparate hypotheses, we used a combination of biochemical, fluorescence imaging, and electron microscopy techniques to quantitatively and dynamically… CONTINUE READING