Quantitative analysis of virus and plasmid trafficking in cells.

  title={Quantitative analysis of virus and plasmid trafficking in cells.},
  author={Thibault Lagache and Emmanuel Dauty and David Holcman},
  journal={Physical review. E, Statistical, nonlinear, and soft matter physics},
  volume={79 1 Pt 1},
  • Thibault Lagache, Emmanuel Dauty, David Holcman
  • Published 2009 in
    Physical review. E, Statistical, nonlinear, and…
Intracellular transport of DNA carriers is a fundamental step of gene delivery. By combining both theoretical and numerical approaches we study here single and several viruses and DNA particles trafficking in the cell cytoplasm to a small nuclear pore. We present a physical model to account for certain aspects of cellular organization, starting with the observation that a viral trajectory consists of epochs of pure diffusion and epochs of active transport along microtubules. We define a general… CONTINUE READING