Quantitative analysis of three-dimensional human mammary epithelial tissue architecture reveals a role for tenascin-C in regulating c-met function.

@article{Taraseviciute2010QuantitativeAO,
  title={Quantitative analysis of three-dimensional human mammary epithelial tissue architecture reveals a role for tenascin-C in regulating c-met function.},
  author={Agne Taraseviciute and Benjamin T Vincent and Pepper J Schedin and Peter Lloyd Jones},
  journal={The American journal of pathology},
  year={2010},
  volume={176 2},
  pages={827-38}
}
Remodeling of the stromal extracellular matrix and elevated expression of specific proto-oncogenes within the adjacent epithelium represent cardinal features of breast cancer, yet how these events become integrated is not fully understood. To address this question, we focused on tenascin-C (TN-C), a stromal extracellular matrix glycoprotein whose expression increases with disease severity. Initially, nonmalignant human mammary epithelial cells (MCF-10A) were cultured within a reconstituted… CONTINUE READING