Quantitative analysis of the loss of muscarinic receptors in various peripheral tissues in M1-M5 receptor single knockout mice.

@article{Ito2009QuantitativeAO,
  title={Quantitative analysis of the loss of muscarinic receptors in various peripheral tissues in M1-M5 receptor single knockout mice.},
  author={Yoshihiko Ito and Luvsandorj Oyunzul and Masanao Seki and Tomomi Fujino Oki and Minoru Matsui and Shizuo Yamada},
  journal={British journal of pharmacology},
  year={2009},
  volume={156 7},
  pages={
          1147-53
        }
}
BACKGROUND AND PURPOSE To compare loss in binding to muscarinic receptor (mAChR) subtypes with their known functions, the total density of muscarinic receptors was measured in peripheral tissues from wild type (WT) and mAChR knockout (KO) mice. EXPERIMENTAL APPROACH Binding parameters of [N-methyl-3H]scopolamine methyl chloride ([3H]NMS) were determined in 10 peripheral tissues of WT and M1-M5 receptor KO mice. Competition between [3H]NMS and darifenacin (selective M3 receptor antagonist) was… CONTINUE READING
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