Quantitative analysis of the interactions between HIV-1 integrase and retroviral reverse transcriptases.

@article{Herschhorn2008QuantitativeAO,
  title={Quantitative analysis of the interactions between HIV-1 integrase and retroviral reverse transcriptases.},
  author={Alon Herschhorn and Iris Oz-Gleenberg and Amnon Hizi},
  journal={The Biochemical journal},
  year={2008},
  volume={412 1},
  pages={163-70}
}
The RT (reverse transcriptase) of HIV-1 interacts with HIV-1 IN (integrase) and inhibits its enzymatic activities. However, the molecular mechanisms underling these interactions are not well understood. In order to study these mechanisms, we have analysed the interactions of HIV-1 IN with HIV-1 RT and with two other related RTs: those of HIV-2 and MLV… CONTINUE READING