Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages.

@article{Malik2009QuantitativeAO,
  title={Quantitative analysis of the human spindle phosphoproteome at distinct mitotic stages.},
  author={Rainer Malik and Ren{\'e} Lenobel and Anna Santamaria and Albert Ries and Erich A. Nigg and Roman K{\"o}rner},
  journal={Journal of proteome research},
  year={2009},
  volume={8 10},
  pages={4553-63}
}
During mitosis, phosphorylation of spindle associated proteins is a key regulatory mechanism for spindle formation, mitotic progression, and cytokinesis. In the recent past, mass spectrometry has been applied successfully to identify spindle proteomes and phosphoproteomes, but did not address their dynamics. Here, we present a quantitative comparison of spindle phosphoproteomes prepared from different mitotic stages. In total, we report the identification and SILAC based relative quantitation… CONTINUE READING

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