Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives

@inproceedings{Tseng2009QuantitativeAO,
  title={Quantitative analysis of the effect of tubulin isotype expression on sensitivity of cancer cell lines to a set of novel colchicine derivatives},
  author={Chih-Yuan Tseng and Jonathan Y. Mane and Philip M. Winter and Lorelei Johnson and Torin Huzil and Elzbieta Izbicka and Richard F. Luduena and Jack Adam Tuszynski},
  booktitle={Molecular Cancer},
  year={2009}
}
A maximum entropy approach is proposed to predict the cytotoxic effects of a panel of colchicine derivatives in several human cancer cell lines. Data was obtained from cytotoxicity assays performed with 21 drug molecules from the same family of colchicine compounds and correlate these results with independent tubulin isoform expression measurements for several cancer cell lines. The maximum entropy method is then used in conjunction with computed relative binding energy values for each of the… CONTINUE READING

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Modification of colchicine cytotoxicity and selectivity through the rational design of novel derivatives

  • JT Huzil, P Winter, +6 authors JA Tuszynski
  • Chemical Biology and Drug Design
  • 2010
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