Quantitative analysis of robustness and fragility in biological networks based on feedback dynamics

  title={Quantitative analysis of robustness and fragility in biological networks based on feedback dynamics},
  author={Yung-Keun Kwon and Kwang-Hyun Cho},
  volume={24 7},
MOTIVATION It has been widely reported that biological networks are robust against perturbations such as mutations. On the contrary, it has also been known that biological networks are often fragile against unexpected mutations. There is a growing interest in these intriguing observations and the underlying design principle that causes such robust but fragile characteristics of biological networks. For relatively small networks, a feedback loop has been considered as an important motif for… 

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