Quantitative analysis of retinal ganglion cell survival with Rbpms immunolabeling in animal models of optic neuropathies.

@article{Kwong2011QuantitativeAO,
  title={Quantitative analysis of retinal ganglion cell survival with Rbpms immunolabeling in animal models of optic neuropathies.},
  author={Jacky M. K. Kwong and Ann V Quan and Haksu Kyung and Natik Piri and Joseph Caprioli},
  journal={Investigative ophthalmology & visual science},
  year={2011},
  volume={52 13},
  pages={9694-702}
}
PURPOSE To investigate whether a recently described retinal ganglion cell (RGC) marker Rbpms (RNA binding protein with multiple splicing) could be used for RGC quantification in various models of RGC degeneration. METHODS Optic nerve crush, excitotoxicity, and elevated intraocular pressure (IOP) rat models were used. Topographic analysis of Rbpms immunolabeling was performed on retinal wholemounts. Retrograde labelings with Fluorogold (FG) and III β-tubulin immunohistochemistry were compared… CONTINUE READING
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