Quantitative analysis of polycomb response elements (PREs) at identical genomic locations distinguishes contributions of PRE sequence and genomic environment

@inproceedings{Okulski2010QuantitativeAO,
  title={Quantitative analysis of polycomb response elements (PREs) at identical genomic locations distinguishes contributions of PRE sequence and genomic environment},
  author={Helena Okulski and Birgit Druck and Sheetal Bhalerao and Leonie Ringrose},
  booktitle={Epigenetics & Chromatin},
  year={2010}
}
Polycomb/Trithorax response elements (PREs) are cis-regulatory elements essential for the regulation of several hundred developmentally important genes. However, the precise sequence requirements for PRE function are not fully understood, and it is also unclear whether these elements all function in a similar manner. Drosophila PRE reporter assays typically rely on random integration by P-element insertion, but PREs are extremely sensitive to genomic position. We adapted the ΦC31 site-specific… CONTINUE READING
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