Quantitative analysis of nucleotide modulation of DNA binding by DnaC protein of Escherichia coli.

@article{Biswas2004QuantitativeAO,
  title={Quantitative analysis of nucleotide modulation of DNA binding by DnaC protein of Escherichia coli.},
  author={Subhasis B. Biswas and Stephen Flowers and Esther E. Biswas-Fiss},
  journal={The Biochemical journal},
  year={2004},
  volume={379 Pt 3},
  pages={553-62}
}
In this study, we have presented the first report of Escherichia coli DnaC protein binding to ssDNA (single stranded DNA) in an apparent hexameric form. DnaC protein transfers DnaB helicase onto a nascent chromosomal DNA replication fork at oriC, the origin of E. coli DNA replication. In eukaryotes, Cdc6 protein may play a similar role in the DNA helicase loading in the replication fork during replication initiation at the origin. We have analysed the DNA-binding properties of DnaC protein and… CONTINUE READING

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