Quantitative analysis of neuronal damage induced by tri-ortho-cresyl phosphate in Wistar rats.

@article{Inui1993QuantitativeAO,
  title={Quantitative analysis of neuronal damage induced by tri-ortho-cresyl phosphate in Wistar rats.},
  author={Keiichiro Inui and Kunitoshi Mitsumori and Takanori Harada and Keizo Maita},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1993},
  volume={20 1},
  pages={111-9}
}
A quantitative analysis of neuronal damage was performed on the fasciculus gracilis (FG) of the cervical spinal cord in male Wistar rats that received orally a single dose of tri-ortho-cresyl phosphate (TOCP) at 1500 mg/kg. FG tissues were sampled at 1, 2, and 3 weeks after treatment and examined histopathologically. Wallerian degeneration of myelinated nerve fibers was observed in FG at 2 weeks. Morphological changes were most evident at 3 weeks after treatment and the number of fibers was… CONTINUE READING

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Axonal atrophy and swelling in organophosphorus - induced delayed neuropathy ( OPIDN ) were evaluated quantitatively using a computer - assisted image analyzer .
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Axonal atrophy and swelling in organophosphorus - induced delayed neuropathy ( OPIDN ) were evaluated quantitatively using a computer - assisted image analyzer .
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