Quantitative analysis of multi-slice Gd-DTPA enhanced dynamic MR images using an automated simplex minimization procedure.

@article{Buckley1994QuantitativeAO,
  title={Quantitative analysis of multi-slice Gd-DTPA enhanced dynamic MR images using an automated simplex minimization procedure.},
  author={David L. Buckley and Robert Kerslake and Stephen J. Blackband and Anthony Horsman},
  journal={Magnetic resonance in medicine},
  year={1994},
  volume={32 5},
  pages={646-51}
}
Quantitative analysis of Gd-DTPA enhanced dynamic MR images has potential for discriminating lesions, especially because the introduction of clinical fast imaging techniques has enabled good sampling of the relatively rapid Gd-DTPA wash-in curves. Analysis of such data requires curve fitting to a nonlinear model, which to date has been performed using a nonlinear least squares (NLLS) fitting procedure. However, this method often fails to converge to the appropriate minima without good initial… CONTINUE READING

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