Quantitative analysis of mononuclear cells expressing human immunodeficiency virus type 1 RNA in esophageal mucosa

@article{Smith1994QuantitativeAO,
  title={Quantitative analysis of mononuclear cells expressing human immunodeficiency virus type 1 RNA in esophageal mucosa},
  author={Philip D. Coleridge Smith and Cecil H. Fox and Henry Masur and Harland S. Winter and David W. Alling},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={180},
  pages={1541 - 1546}
}
The mucosa of the gastrointestinal tract is presumably an important reservoir for human immunodeficiency virus type 1 (HIV-1), but the level of virus-expressing cells within the mucosa of infected patients is not known. To study this issue, we identified HIV-1 mRNA-expressing (positive) mononuclear cells by in situ hybridization in specimens of esophageal mucosa from eight patients with acquired immune deficiency syndrome (AIDS) and esophageal infections. Such cells were not found in four… CONTINUE READING

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