Quantitative analysis of mitochondrial DNA deletions in the brains of patients with bipolar disorder and schizophrenia.

@article{Kakiuchi2005QuantitativeAO,
  title={Quantitative analysis of mitochondrial DNA deletions in the brains of patients with bipolar disorder and schizophrenia.},
  author={Chihiro Kakiuchi and Mizuho Ishiwata and Mizue Kametani and Cheryl R Nelson and Kazuya Iwamoto and Tadafumi Kato},
  journal={The international journal of neuropsychopharmacology},
  year={2005},
  volume={8 4},
  pages={515-22}
}
Several clinical, genetic and neuroimaging studies implicate mitochondrial dysfunction in the pathophysiology of bipolar disorder and schizophrenia. It has been reported that a mitochondrial DNA (mtDNA) deletion of 4,977 bp, known as the 'common deletion', is associated with both mental illnesses. A lack of normal age-related accumulation of this deletion in schizophrenia and increased occurrence of the common deletion in bipolar disorder have been reported. However, even in the affected… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 19 extracted citations

Similar Papers

Loading similar papers…