Quantitative analysis of mitochondrial DNA 4977-bp deletion in sporadic breast cancer and benign breast diseases

@article{Ye2007QuantitativeAO,
  title={Quantitative analysis of mitochondrial DNA 4977-bp deletion in sporadic breast cancer and benign breast diseases},
  author={Chuanzhong Ye and Xiao-ou Shu and Wanqing Wen and Larry Pierce and Regina Courtney and Yu-tang Gao and Wei Zheng and Qiuyin Cai},
  journal={Breast Cancer Research and Treatment},
  year={2007},
  volume={108},
  pages={427-434}
}
The mitochondrial DNA (mtDNA) 4977-bp deletion (ΔmtDNA4977 mutation) is one of the most frequently observed mtDNA mutations in human tissues and may play a role in carcinogenesis. Only a few studies have evaluated ΔmtDNA4977 mutation in breast cancer tissue, and the findings have been inconsistent, which may be due to methodological differences. In this study, we developed a quantitative real-time PCR assay to assess the level of the ΔmtDNA4977 mutation in tumor tissue samples from 55 primary… CONTINUE READING

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