Quantitative analysis of metabolite concentrations in human urine samples using 13C{1H} NMR spectroscopy

  title={Quantitative analysis of metabolite concentrations in human urine samples using 13C\{1H\} NMR spectroscopy},
  author={Rustem Shaykhutdinov and Glen D. MacInnis and Reza Dowlatabadi and Aalim M Weljie and Hans J. Vogel},
Targeted profiling is a library-based method of using mathematically modeled reference spectra for quantification of metabolite concentrations in NMR mixture analysis. Metabolomics studies of biofluids, such as urine, represent a highly complex problem in this area, and for this reason targeted profiling of 1H NMR spectra can be hampered. A number of the issues relating to 1H NMR spectroscopy can be overcome using 13C{1H} NMR spectroscopy. In this work, a 13C{1H} NMR database was created using… CONTINUE READING


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