Quantitative analysis of mRNA expression levels and DNA methylation profiles of three neighboring genes: FUS1, NPRL2/G21 and RASSF1A in non-small cell lung cancer patients

@inproceedings{PastuszakLewandoska2015QuantitativeAO,
  title={Quantitative analysis of mRNA expression levels and DNA methylation profiles of three neighboring genes: FUS1, NPRL2/G21 and RASSF1A in non-small cell lung cancer patients},
  author={Dorota Pastuszak-Lewandoska and Jacek Kordiak and Monika Migdalska-Sęk and Karolina H. Czarnecka and Adam Antczak and Paweł G{\'o}rski and Ewa Nawrot and Justyna M Kiszałkiewicz and Daria Domańska and Ewa Brzeziańska-Lasota},
  booktitle={Respiratory Research},
  year={2015}
}
BackgroundTumor suppressor gene (TSG) inactivation plays a crucial role in carcinogenesis. FUS1, NPRL2/G21 and RASSF1A are TSGs from LUCA region at 3p21.3, a critical chromosomal region in lung cancer development. The aim of the study was to analyze and compare the expression levels of these 3 TSGs in NSCLC, as well as in macroscopically unchanged lung tissue surrounding the primary lesion, and to look for the possible epigenetic mechanism of TSG inactivation via gene promoter methylation… CONTINUE READING
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Expression level and methylation status of three tumor suppressor genes, DLEC1, ITGA9 and MLH1, in non-small cell lung cancer

Dorota Pastuszak-Lewandoska, Jacek Kordiak, +7 authors Ewa Brzeziańska-Lasota
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  • 2016
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