Quantitative analysis of liposome-cell interactions in vitro: rate constants of binding and endocytosis with suspension and adherent J774 cells and human monocytes.

@article{Lee1993QuantitativeAO,
  title={Quantitative analysis of liposome-cell interactions in vitro: rate constants of binding and endocytosis with suspension and adherent J774 cells and human monocytes.},
  author={Keun Deuk Lee and S. Nir and Demetrios Papahadjopoulos},
  journal={Biochemistry},
  year={1993},
  volume={32 3},
  pages={
          889-99
        }
}
We have characterized the parameters describing the total association (uptake) of liposomes with murine macrophage-like cell line J774 cells and human peripheral blood monocytes at 4 degrees C and at 37 degrees C with or without inhibitors of endocytosis. The uptake of neutral liposomes composed of phosphatidylcholine (PC)/cholesterol (Chol) (2:1 mole ratio) is about 10-fold lower than that of negatively charged liposomes composed of phosphatidylserine (PS)/PC/Chol (1:1:1). However, the rate of… CONTINUE READING

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