Quantitative analysis of estrogen receptor heterogeneity in breast cancer

  title={Quantitative analysis of estrogen receptor heterogeneity in breast cancer},
  author={Gina G. Chung and Maciej P Zerkowski and Sriparna Ghosh and Robert L. Camp and David L. Rimm},
  journal={Laboratory Investigation},
Immunohistochemical analyses (IHC) of biomarkers are extensively used for tumor characterization and as prognostic and predictive measures. The current standard of single slide analysis assumes that one 5 μM section is representative of the entire tumor. We used our automated image analysis technology (AQUA) using a modified IHC technique with fluorophores to compare estrogen receptor (ER) expression in multiple blocks/slides from cases of primary breast cancer with the objective of quantifying… CONTINUE READING
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