Quantitative analysis of bone marrow thymic progenitors in young and aged mice.

@article{Eren1990QuantitativeAO,
  title={Quantitative analysis of bone marrow thymic progenitors in young and aged mice.},
  author={R Canan Eren and Amiela Globerson and Loya Abel and Dorit Zharhary},
  journal={Cellular immunology},
  year={1990},
  volume={127 2},
  pages={238-46}
}
Our studies on the capacity of bone marrow (BM) to generate T lymphocytes in aging have revealed that under the competitive conditions of thymic reconstitution, cells of aged mice are significantly inferior to those of the young. The present study was designed to further investigate the basis of this age-related change. Two mechanisms were considered: (a) The potential of BM-derived T cell precursors from aged mice to proliferate and differentiate in the thymic microenvironment is impaired. (b… CONTINUE READING

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