Quantitative analysis of an anaphase B switch: predicted role for a microtubule catastrophe gradient

@article{Cheerambathur2007QuantitativeAO,
  title={Quantitative analysis of an anaphase B switch: predicted role for a microtubule catastrophe gradient},
  author={Dhanya K. Cheerambathur and Gul Civelekoglu-Scholey and Ingrid Brust-Mascher and Patrizia Sommi and Alex Mogilner and Jonathan M. Scholey},
  journal={The Journal of Cell Biology},
  year={2007},
  volume={177},
  pages={995 - 1004}
}
Anaphase B in Drosophila embryos is initiated by the inhibition of microtubule (MT) depolymerization at spindle poles, which allows outwardly sliding interpolar (ip) MTs to drive pole-pole separation. Using fluorescence recovery after photobleaching, we observed that MTs throughout the preanaphase B spindle are very dynamic and display complete recovery of fluorescence, but during anaphase B, MTs proximal to the poles stabilize and therefore display lower recovery than those elsewhere… CONTINUE READING

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