Quantitative analysis of F‐actin redistribution in astrocytoma cells treated with candidate pharmaceuticals

@article{Lockett2014QuantitativeAO,
  title={Quantitative analysis of F‐actin redistribution in astrocytoma cells treated with candidate pharmaceuticals},
  author={Stephen J. Lockett and Chrissie Verma and Alla Brafman and Prabhakar R. Gudla and Kaustav Nandy and Yoshihiro Mimaki and Philip L. Fuchs and Joseph Jaja and Karlyne M. Reilly and John A. Beutler and Thomas Turbyville},
  journal={Cytometry Part A},
  year={2014},
  volume={85}
}
Actin fibers (F‐actin) control the shape and internal organization of cells, and generate force. It has been long appreciated that these functions are tightly coupled, and in some cases drive cell behavior and cell fate. The distribution and dynamics of F‐actin is different in cancer versus normal cells and in response to small molecules, including actin‐targeting natural products and anticancer drugs. Therefore, quantifying actin structural changes from high resolution fluorescence micrographs… Expand
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