Quantitative analysis of DNA-cleaving activities of macromomycin, auromomycin, and their free chromophores, and some DNA-binding characteristics.

Abstract

The in vitro DNA-cutting activities of macromomycin (MCR), auromomycin (AUR), and their free chromophores were quantitatively analyzed by agarose gel electrophoresis of radioactive supercoiled pBR322 DNA. Methanol extract (chromophore) of MCR inhibited growth of cultured L5178Y cells and caused DNA strand scission without addition of reducing agents… (More)

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