Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET.

@article{Farde1986QuantitativeAO,
  title={Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET.},
  author={Lars Farde and Haakan Hall and Erling Ehrin and G{\"o}ran Sedvall},
  journal={Science},
  year={1986},
  volume={231 4735},
  pages={258-61}
}
D2 dopamine receptors in the putamen of living human subjects were characterized by using the selective, high-affinity D2 dopamine receptor antagonist carbon-11-labeled raclopride and positron emission tomography. Experiments in four healthy men demonstrated saturability of [11C]raclopride binding to an apparently homogeneous population of sites with Hill coefficients close to unity. In the normal putamen, maximum binding ranged from 12 to 17 picomoles per cubic centimeter and dissociation… CONTINUE READING