Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation.

@article{Wang2007QuantitativeAR,
  title={Quantitative analyses reveal the importance of regulated Hdmx degradation for p53 activation.},
  author={Yunyuan V. Wang and Mark Wade and Eetsin Wong and Y Li and Luo Wei Rodewald and Geoffrey M. Wahl},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 30},
  pages={12365-70}
}
P53 regulates numerous downstream targets to induce cell cycle arrest, senescence, apoptosis, and DNA repair in response to diverse stresses. Hdm2 and Hdmx are critical negative regulators of P53 because Hdm2 regulates P53 abundance, and both can antagonize P53 transactivation. Modest changes in Hdm2 or Hdmx abundance affect P53 regulation, yet quantitative information regarding their endogenous intracellular concentrations and subcellular distributions during a stress response are lacking. We… CONTINUE READING