Quantitative analyses of antagonism: combinations of midazolam and either flunitrazepam or pregnanolone in rhesus monkeys discriminating midazolam.

@article{Gerak2012QuantitativeAO,
  title={Quantitative analyses of antagonism: combinations of midazolam and either flunitrazepam or pregnanolone in rhesus monkeys discriminating midazolam.},
  author={Lisa R. Gerak and Charles P France},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2012},
  volume={340 3},
  pages={742-9}
}
Adverse effects of benzodiazepines limit their clinical use; these effects might be reduced without altering therapeutic effects by administering other positive GABA(A) modulators (i.e., neuroactive steroids) with benzodiazepines. One concern with this strategy involves reversing these combined effects in case of overdose. The current study examined whether… CONTINUE READING