Quantitative affinity purification mass spectrometry: a versatile technology to study protein–protein interactions

@inproceedings{Meyer2015QuantitativeAP,
  title={Quantitative affinity purification mass spectrometry: a versatile technology to study protein–protein interactions},
  author={Katrina Meyer and Matthias Selbach},
  booktitle={Front. Genet.},
  year={2015}
}
While the genomic revolution has dramatically accelerated the discovery of disease-associated genes, the functional characterization of the corresponding proteins lags behind. Most proteins fulfill their tasks in complexes with other proteins, and analysis of protein-protein interactions (PPIs) can therefore provide insights into protein function. Several methods can be used to generate large-scale protein interaction networks. However, most of these approaches are not quantitative and… CONTINUE READING
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