Quantitative Ultrasound of the Heel and Some Parameters of Bone Turnover in Patients with Acromegaly

@article{Bolanowski2002QuantitativeUO,
  title={Quantitative Ultrasound of the Heel and Some Parameters of Bone Turnover in Patients with Acromegaly},
  author={Marek Bolanowski and Diana Jędrzejuk and Andrzej Milewicz and Anna Arkowska},
  journal={Osteoporosis International},
  year={2002},
  volume={13},
  pages={303-308}
}
Acromegaly caused by growth hormone (GH) hypersecretion is characterized by enhanced skeletal growth and soft tissue enlargement. Insulin-like growth factor-1 (IGF-1) is the main peripheral mediator of GH action and it has a crucial role in the maintenance of a normal bone mass. However, in some patients with acromegaly, secondary osteoporosis is observed, despite the strong anabolic effect of GH and IGF-1 in bones. It is thought to be due to hypogonadism. The bone changes are accompanied by… CONTINUE READING
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