Quantitative UPLC-MS/MS analysis of underivatised amino acids in body fluids is a reliable tool for the diagnosis and follow-up of patients with inborn errors of metabolism.

@article{Waterval2009QuantitativeUA,
  title={Quantitative UPLC-MS/MS analysis of underivatised amino acids in body fluids is a reliable tool for the diagnosis and follow-up of patients with inborn errors of metabolism.},
  author={W. A. Huub Waterval and Jean Ljm Scheijen and Marjon M J C Ortmans-Ploemen and Catharina D Habets-van der Poel and J{\"o}rgen Bierau},
  journal={Clinica chimica acta; international journal of clinical chemistry},
  year={2009},
  volume={407 1-2},
  pages={
          36-42
        }
}
BACKGROUND An electro-spray ionisation ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) application for the quantitative analysis of amino acids was developed. The suitability for the detection and follow-up of patients suffering from inborn errors of metabolism (IEM) was assessed by extensive cross-validation with ion-exchange liquid chromatography (IEX-LC) with post-column ninhydrin derivatisation, participation in external quality control (ERNDIM) and analysis of… CONTINUE READING

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