Quantitative Tracking of Isotope Flows in Proteomes of Microbial Communities*

@inproceedings{Pan2011QuantitativeTO,
  title={Quantitative Tracking of Isotope Flows in Proteomes of Microbial Communities*},
  author={Chongle Pan and Curt R. Fischer and Doug Hyatt and Benjamin P. Bowen and Robert L. Hettich and Jillian F. Banfield},
  booktitle={Molecular & cellular proteomics : MCP},
  year={2011}
}
Stable isotope probing (SIP) has been used to track nutrient flows in microbial communities, but existing protein-based SIP methods capable of quantifying the degree of label incorporation into peptides and proteins have been demonstrated only by targeting usually less than 100 proteins per sample. Our method automatically (i) identifies the sequence of and (ii) quantifies the degree of heavy atom enrichment for thousands of proteins from microbial community proteome samples. These features… CONTINUE READING

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