Quantitative T-cell interferon-gamma responses to Mycobacterium tuberculosis-specific antigens in active and latent tuberculosis

@article{Chee2008QuantitativeTI,
  title={Quantitative T-cell interferon-gamma responses to Mycobacterium tuberculosis-specific antigens in active and latent tuberculosis},
  author={Cynthia B E Chee and Timothy Mark Sebastian Barkham and Kyi W Khinmar and Suay Hong Gan and Yee Tang Sonny Wang},
  journal={European Journal of Clinical Microbiology & Infectious Diseases},
  year={2008},
  volume={28},
  pages={667-670}
}
The objective was to compare the quantitative T-cell responses measured by the commercial interferon-gamma (IFNγ) release assays (IGRAs) in active and latent tuberculosis (TB) states. T-cell responses of culture-proven TB cases were compared with those of contacts with positive IGRA results and tuberculin skin tests ≥ 15 mm. T-SPOT.TB results in 270 active TB cases and 183 community contacts showed the median spot-forming cells (SFCs) above negative control/2.5 × 105 peripheral blood… CONTINUE READING
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